Targeted Treatments for Triple Negative Breast Cancer
Thanks to generous funding from Tour de Cure, riders and supporters in 2019, an international research project is hoping to uncover the ‘magic bullet’ for treating Triple Negative Breast Cancer – one of the most aggressive and fatal forms of breast cancer.
Flinders University Professor Arduino Mangoni is nearing completion of the first stage of the study, investigating a newly developed drug compound targeting the enzyme DDAH1 in Triple Negative Breast Cancer.
With this cancer type affecting around 15-20 per cent of women with breast cancer, and no targeted therapies currently available, Prof Mangoni said a breakthrough was desperately needed in this field.
“This a pretty common form of cancer, and sadly it seems to be more aggressive with significantly worse survival compared with other breast cancer types,”
“And while there have been major advances in improving treatment and mortality rates, and reducing the risk of relapse in other types of breast cancer, unfortunately in the case of Triple Negative Breast Cancer there hasn’t been that same progression and it lags behind in available therapies.
“As yet, there’s no magic bullet treatment.”
But in collaboration with researchers in Milan, Italy and Aberdeen, Scotland, Professor Mangoni has shown his drug is effective in a laboratory setting to block – vasculogenic mimicry - a mechanism which is used by Triple Negative Breast Cancer to spread cells.
Current trials are now exploring how the drug is distributed and absorbed throughout the body, and if results are promising Professor Mangoni hopes to investigate its impact on reducing cancer size and the number of metastases before hopefully progressing to human trials in future.
“There’s now so much focus on making targeted treatments available to give people the best chance of survival, and our work seeks to help those women who are sadly at risk of the worst outcome,” Professor Mangoni says.
Riding For My Research
When Flinders University cancer researcher Dr Ashley Hopkins jumped on his bike to join the 2019 SA Discovery Tour, he was overwhelmed by the support those riding alongside him gave to his research.
32 new health and medical research projects… thanks to you!
At a time when the focus on health and medical research has never been greater, 32 exciting new projects across the Flinders medical precinct have received funding in Flinders Foundation’s annual Health Seed Grant Round.
Rachel’s dream is to improve therapies to treat, and ultimately cure, multiple myeloma.
“Multiple myeloma is incurable, that’s something we’d obviously like to change.”
Protein discovery paves way for new multiple myeloma treatments
Multiple myeloma patients with the poorest prognosis are set to benefit from promising new research
Promising blood test to detect head and neck cancer
Researchers at Flinders University hope their promising blood test model could help to diagnose a common form of head and neck cancer, in the same way diagnostic tests are available for other cancer types.
Heart Pillows for Heart Patients – Aboriginal and Torres Strait Islander Health –
Aboriginal and Torres Strait Islander patients undergoing heart surgery at Flinders Medical Centre (FMC) are being gifted ‘heart pillows’
Introducing Brett Stringer – Brain Cancer Research Fellowship
Dr Brett Stringer has been appointed to a new three-year Brain Cancer Research Fellowship at Flinders University, funded by Flinders Foundation.
Thyroid research under the microscope
Flinders University medical student Lauren Rask-Nielsen has received a research scholarship to take a closer look at the diagnosis of thyroid nodules which can, in some instances, be cancerous.
Flinders’ COVID-19 patients key to beating virus
As the world waits with bated breath for a vaccine to fight COVID-19, 30 former COVID-19 positive patients have gifted their blood to Flinders researchers in a bid to find ‘super-antibodies’ to use as a weapon to beat the virus.
Help for critically ill patients
Critically ill patients and those recovering from major surgeries have been helped in their recovery with the arrival of new chairs and stand aids to get them out of bed sooner.